Seminar khoa học của TS. Pirun Mikled và TS. Lê Đình Tuấn

Vào 14h00, ngày 04/04/2025 Viện IAST tổ chức buổi trao đổi học thuật tại Phòng họp B

TS. Pirun Mikled trình bày về "Dual folate/biotin-decorated liposomes mediated delivery of methylnaphthazarin for anti-cancer activity"
Abstract: Chemotherapy is an effective strategy for mitigating the global challenge of cancer treatment, which often encounters drug resistance and negative side effects. Methylnaphthazarin (MNZ), a natural compound with promising anti-cancer properties, has been underexplored due to its poor aqueous solubility and low selectivity. This study introduces a novel approach to overcome these limitations by developing MNZ-encapsulating liposomes decorated with folate and biotin (F/B-LP-MNZ). This dual-targeting strategy aims to enhance the anti-cancer efficacy and specificity of MNZ delivery. Our innovative F/B-LP-MNZ formulation demonstrated excellent physicochemical properties, stability, and controlled drug release profiles. In vitro studies revealed that MNZ-loaded liposomes attenuate the toxicity associated with free MNZ while F/B-LP-MNZ significantly increased cytotoxicity against HeLa cells, which express high levels of folate and biotin receptors, compared to non-targeted liposomes. Enhanced cellular uptake and improved dynamic flow attachment further confirmed the superior specificity of F/B-LP in targeting cancer cells. Additionally, our results revealed that F/B-LP-MNZ effectively inhibits HeLa cell migration and adhesion through EMT suppression and apoptotic induction, indicating its potential to prevent cancer metastasis. These findings highlight the potential of dual folate and biotin receptors-targeting liposomes as an effective delivery system for MNZ, offering a promising new avenue for targeted cancer therapy.

TS. Lê Đình Tuấn trình bày về "Study on the adsorption of L-histidine on carbon nanotube at different temperatures based on cluster adsorption model and structure optimization process"
Abstract: This study constructed the adsorption isotherms of L-histidine on MKN-SWCNT S1 single-walled carbon nanotubes in the aqueous solution at 25, 35, 45, 55, 65, and 80 oC. The isotherms belong to types IV and V according to the IUPAC classification. The results showed that with increasing temperature, the adsorption capacity of carbon nanotubes gradually decreased. The experimental isotherms were analyzed based on the cluster adsorption model. The results showed a good agreement between the theoretical model and the experiment, with r2 values ranging from 0.996 to 0.999. According to the cluster model, the dipole ions adsorbed on the CNT surface in the form of monomers (low concentration region) and clusters (high concentration region) with different sizes: 13 (25℃), 8 (35℃) and 7 (35, 45, 55, 65, 80℃). Based on the value of K1, the thermodynamic parameters of the adsorption process were also calculated. The mechanism of the adsorption process was determined based on the quantum calculation results of the structure optimization process. Parameters such as adsorption energy, the distance between reaction centers, etc. were determined. The results of adsorption studies of L-histidine dipolar ions as monomers and dimers both showed that the most likely mechanism for amino acid immobilization on CNTs is Van der Waals forces and (π-π) stacking interactions between the imidazole ring of L-histidine and carbon nanotubes.