Prof. Zhan Peng

TDTU, 15/06/2026

Full name: Prof. Zhan Peng

Number of publications (WoS): 434

H-index (WoS): 54

 

Main research direction:

  1. Research on broad-spectrum anti-resistance antiviral drugs based on rational design and phenotypic screening (focusing on difficult-to-cure viral infections such as AIDS and hepatitis B; respiratory viral infections such as influenza virus, coronavirus, RSV; and other emerging and recurrent viral infections);
  1. Research on innovative drugs for major chronic diseases such as gout, hyperuricemia, and uric acid nephropathy based on virtual screening and pharmacophore models ;
  1. Research on construction technology of drug-like compound library and efficient screening methods.

 

Projects to be undertaken

  1. National Key R&D Program (2023YFC2606500), 2023.11-2025.10
  2. National Natural Science Foundation of China (82173677), 2022.01-2024.12
  3. National Natural Science Foundation of China International (Regional) Cooperation and Exchange Project (82211530493), 2023.01-2024.12
  4. Shandong Outstanding Youth Fund (ZR2020JQ31), 2021.1-2023.12
  5. Shandong Provincial Major Science and Technology Innovation Project (2019JZZY021011), 2019.01-2021.12
  6. Shandong University "Outstanding Young and Middle-aged Scholars" Research Fund, 2022/01-2026/12
  7. National Natural Science Foundation of China (81573347), 2016.01-2019.12
  8. National Natural Science Foundation of China Youth Project (81102320), 2012.01-2014.12
  9. Special Research Fund for Doctoral Programs in Higher Education Institutions (20110131120037), 2012.01-2015.12
  10. 10.Shandong Science and Technology Development Project (2014GSF118012), 2015.1-2017.12

Teaching and Research Projects

  1. 2023 Shandong Province Undergraduate Teaching Reform Research Project (General, M2023290)
  2. 2023 Qilu Medical Characteristic Undergraduate Education and Teaching Research Project (Key)
  3. 2023 Shandong University Education and Teaching Reform Research Project
  4. 2021 Shandong University Qilu Medical Characteristic Undergraduate Education and Teaching Research Project (qlyxjy-202106)
  5. 2021 Shandong University Course Ideological and Political Demonstration Construction Project (2021S22)
  6. 2021 Shandong University Education and Teaching Reform Research Project (2021Y026)
  7. 2020 Shandong University Qilu Medical College Undergraduate Teaching Reform and Research Project (qlyxjy-202010)
  8. 2019 Shandong University Education and Teaching Reform Research Project (2019Y278)
  9. 2017 Shandong University Qilu Medical College Undergraduate Teaching Reform and Research Project (qlyxjy-201743)
  10. Teaching and Research Project for Young Teachers of School of Pharmacy, Shandong University (2016, 2017)

Representative scientific research papers

  1. Ma Y, Frutos-Beltrán E, Kang D, Pannecouque C, De Clercq E, Menéndez-Arias L, Liu X, Zhan P . Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses. Chem Soc R ev . 2021 ;50(7):4514-4540.
  2. Xu S, Sun L, Barnett M, Zhang X, Ding D, Gattu A, Shi D, Taka JRH, Shen W, Jiang X, Cocklin S, De Clercq E, Pannecouque C, Goldstone DC , Liu Capsid Modulators. J Med Chem . 2023 ;66(23):16303-16329.
  3. Gao S, Sylvester K, Song L, Claff T, Jing L, Woodson M, Weiße RH, Cheng Y, Schäkel L, Petry M, Gütschow M, Schiedel AC, Sträter N, Kang D, Xu S, Toth K, Tavis J, Tollefson AE, Müller CE, Liu X, Zhan P . Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity. J Med Chem . 2022 ;65(19):13343-13364.
  4. Li P , Ju H, Zhang Y, Achi JG, Kang D, Zou J, Du R, Cui Q, Liu X, Rong L, Zhan P . Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses. J Med Vir ol. 2023 ;95(7):e28968.
  5. 5.Gao S, Song L, Sylvester K, Mercorelli B, Loregian A, Toth K, Weiße RH, Useini A, Sträter N, Yang M, Ye B, Tollefson AE, Müller CE, Liu X, Zhan P . Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability. J Med Chem. 2023 ;66(23):16426-16440.
  1. Jiang X, Sharma PP , Rathi B, Ji X, Hu L, Gao Z, Kang D, Wang Z, Xie M, Xu S, Zhang X, De Clercq E, Cocklin S, Pannecouque C, Dick A , Liu Vir ol. 2022 ;94(12):5975-5986.
  2. Zhao T, Zhang J, Tao Y, Liao H, Zhao F, Liang R, Shi X, Zhang Z, Ji J, Wu T, Pang J, Liu X, Zhan P . Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability. J Med Chem . 2022 ;65(5):4218-4237.
  3. Sun L, Dick A, Meuser ME, Huang T, Zalloum WA, Chen CH, Cherukupalli S, Xu S, Ding X, Gao P , Kang D, De Clercq E, Pannecouque C, Cocklin S, Lee KH, Liu X, Zhan P . Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities. J Med Chem . 2020 ;63(9):4790-4810.
  4. Zhao T, Meng Q, Sun Z, Chen Y, Ai W, Zhao Z, Kang D, Dong Y, Liang R, Wu T , P ang J , Liu
  5. Ju H, Murugan NA, Hou L, Li P , Guizzo L, Zhang Y, Bertagnin C, Kong X, Kang D, Jia R, Ma X, Du R, Poongavanam V, Loregian A, Huang B , Liu Favorable Druggability. J Med Chem . 2021 ;64(24):17992-18009.

Representative Teaching and Research Papers

  1. Zhan Peng . University Chemistry, 2023, 38 (12): 1-9.
  2. Zhan Peng , Liu Xinyong. University Chemistry, 2023, 38 (12): 10-17.
  3. Zhan Peng , Xu Shujing, Liu Xinyong. Pharmaceutical Education, 2022, 38(04): 49-54.
  4. Zhan Peng , Liu Xinyong. Pharmaceutical Education, 2022, 38(03): 30-34.
  5. Zhan Peng , Liu Xinyong. University Chemistry, 2022, 37(11): 77-82.
  6. Zhan Peng , Liu Xinyong. Pharmaceutical Education, 2021, 37, 36-39.
  7. Zhan Peng , Liu Xinyong. University Chemistry, 2021, 36, 73-81.
  8. Zhan Peng , Liu Xinyong. University Chemistry, 2021, 36, 51-56.
  9. Zhan Peng , Liu Xinyong. University Chemistry, 2020, 35(02): 14-20.
  10. Zhan Peng , Liu Xinyong. University Chemistry, 2019, 34, 68-73.
  11. Zhan Peng , Jiang Xiaofei, Wang Yiming, Lan Gongde, Liu Xinyong. University Chemistry, 2019, 34, 61-67.
  12. Zhan Peng , Kang Dongwei, Qu Zhiyan, Yu Lubing, Liu Xinyong. Pharmaceutical Education, 2018, 34, 43-47+67.
  13. Gao Yuan, Liu Xinyong, Zhan Peng *. University Chemistry, 2022, 37(11): 70-76.
  14. Yu Mingxuan, Lü Kaige, Yu Han, Zhang Yuqi, Zhan Peng * , Liu Xinyong*. Pharmaceutical Education, 2023, 39 (06): 75-79.

Authorized invention patent (first place)

  1. Zhan Peng , et al. Patent No.: ZL201310718150.1
  2. Zhan Peng , etc. Patent No.: ZL201810088488.6
  3. Zhan Peng , et al. Patent No.: ZL201810426499.0
  4. Zhan Peng , et al. Patent No.: ZL201810763420.3
  5. Zhan Peng , etc. Patent No.: ZL201810800211.1
  6. Zhan Peng , et al. Patent No.: ZL201910136934.0
  7. Zhan Peng , etc. Patent No.: ZL201910592039.X
  8. Zhan Peng , et al. Patent No.: ZL202010600374.2
  9. Zhan Peng , et al. Patent No.: ZL202010600383.1
  10. 10. Zhan Peng , et al. Patent No.: ZL202110436413.4
  11. Zhan Peng , et al. Patent No.: ZL202110451567.0
  12. Zhan Peng , et al. Patent No.: ZL202110684929.0
  13. Zhan Peng , et al. Patent No.: ZL202111188493.2
  14. Zhan Peng , et al. Patent No.: ZL202111224728.9
  15. Zhan Peng , et al. Patent No.: ZL202210011677.X
  16. Zhan Peng , et al. Patent No.: ZL202210076418.5
  17. Zhan Peng , et al. Patent No.: ZL202110759172.7
  18. Zhan Peng , et al. Patent No.: ZL202210694873.1
  19. Zhan Peng , et al. Patent No.: ZL202110625655.8
  20. Zhan Peng , et al. Patent No.: ZL202110452224.6
  21. Zhan Peng , et al. Patent No.: ZL202210157554.7
  22. Zhan Peng , et al. Patent No.: ZL202210098964.9
  23. Zhan Peng , et al. Patent No.: ZL202210498051.6
  24. Zhan Peng , et al. Patent No.: ZL202210497951.9

Awards and Honors

Scientific research awards (limited to 10 items):

  1. The 19th China Pharmaceutical Association-Servier Young Medicinal Chemistry Award
  2. The 37th International Antiviral Academic Conference Travel Award
  3. First Prize of Shandong Higher Education Outstanding Scientific Research Achievement Award (second place)
  4. Yinfeng Outstanding Young Teachers Research Award of Qilu Medical College of Shandong University
  5. Japan Society for the Promotion of Science (JSPS) Special Researcher Scholarship
  6. Nominated for the National Outstanding Doctoral Dissertation of the Ministry of Education, Outstanding Doctoral Dissertation of Shandong Province, Outstanding Doctoral Dissertation of Shandong University,
  1. Second Prize for Outstanding Papers at the 13th Youth Pharmaceutical Research Achievement Exchange Conference of the Chinese Pharmaceutical Association
  2. First Prize for Outstanding Papers at the 14th China Pharmaceutical Society Youth Pharmacy Forum
  3. Excellent Report Award for Young Scholars at the China Medicinal Chemistry Academic Conference
  4. Young top talents of School of Pharmacy, Shandong University School of Pharmacy (2022)