Prof. Horng Jim-Tong

TDTU, 12/06/2026

Full name: Prof. Horng Jim-Tong

Number of publications (WoS): 81

H-index (WoS): 28

 

Main research direction:

  • RNA viruses, such as Enterovirus A71 and influenza viruses, with a particular focus on virus–host interactions and antiviral development.
  • Development of small molecules and botanical drugs that effectively inhibit several RNA viruses, including SARS-CoV-2.

Peer-reviewed Publications for last five years

  1. Chin, Y.F., Tang, W.F., Chang, Y.H., Chang, T.Y., Lin, W.C., Lin, C.Y., Yang, C.M., Wu, H.L., Liu, P.C., Sun, J.R., et al. (2022). Orally delivered perilla (Perilla frutescens) leaf extract effectively inhibits SARS-CoV-2 infection in a Syrian hamster model. J Food Drug Anal 30, 252-270.
  1. Jheng, J.R., Hsieh, C.F., Chang, Y.H., Ho, J.Y., Tang, W.F., Chen, Z.Y., Liu, C.J., Lin, T.J., Huang, L.Y., Chern, J.H., et al. (2022). Rosmarinic acid interferes with influenza virus A entry and replication by decreasing GSK3beta and phosphorylated AKT expression levels. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 55, 598-610.
  1. Hsieh, C.F., Chen, Y.L., Lin, G.H., Chan, Y.F., Hsieh, P.W., and Horng*, J.T. (2022). 3,4-Dicaffeoylquinic Acid from the Medicinal Plant Ilex kaushue Disrupts the Interaction Between the Five-Fold Axis of Enterovirus A-71 and the Heparan Sulfate Receptor. Journal of virology 96, e0054221.
  1. Tang, W.F., Tsai, H.P., Chang, Y.H., Chang, T.Y., Hsieh, C.F., Lin, C.Y., Lin, G.H., Chen, Y.L., Jheng, J.R., Liu, P.C., et al. (2021). Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation. Biomed J 44, 293-303.
  1. Chu, H.W., Sethy, B., Hsieh, P.W., and Horng*, J.T. (2021). Identification of Potential Drug Targets of Broad-Spectrum Inhibitors with a Michael Acceptor Moiety Using Shotgun Proteomics. Viruses 13.
  1. Hsieh, C.F., Jheng, J.R., Lin, G.H., Chen, Y.L., Ho, J.Y., Liu, C.J., Hsu, K.Y., Chen, Y.S., Chan, Y.F., Yu, H.M., et al. (2020). Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors. Emerg Microbes Infect 9, 1194-1205.
  1. Jheng, J.R., Chen, Y.S., and Horng*, J.T. (2021). Regulation of the proteostasis network during enterovirus infection: A feedforward mechanism for EV-A71 and EV-D68. Antiviral research 188, 105019.
  1. Sethy, B., Hsieh, C.F., Lin, T.J., Hu, P.Y., Chen, Y.L., Lin, C.Y., Tseng, S.N., Horng*, J.T., and Hsieh*, P.W. (2019). Design, Synthesis, and Biological Evaluation of Itaconic Acid Derivatives as Potential Anti-Influenza Agents. Journal of medicinal chemistry 62, 2390-2403.
  1. Tang, W. F., Huang, R. T., Chien, K. Y., Tang, P., and Horng*, J. T. (2018) Large- Scale Proteomic Identification of Targets of Cellular miR-197 Downregulated by Enterovirus A71. Journal of proteome research doi: 10.1021/acs.jproteome.8b00762
  1. Jheng, J. R., Lau, K. S., Lan, Y. W., and Horng, J. T. (2018) A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability. Journal of biomedical science 25, 9
  1. Chang, Y. H., Lau, K. S., Kuo, R. L., and Horng*, J. T. (2017) dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication. Front Cell Infect Microbiol 7, 284

Research Support

Ongoing Research Support

MOST 109-2320-B-182 -026 -MY3 Horng (PI) 2020/08/01 ~ 2023/07/31

Mechanistic study of an itaconic acid derivative that inhibits nlcear export ofnucleoprotein of influenza virus

MOST 109-2634-F-182-001 Horng (co-PI) 2021/03/01 ~ 2023/02/28

The Featured Areas Research Center Program within the framework of the Higher

Education Sprout Project by the Ministry of Education (MOE) in Taiwan and the

Ministry of Science and Technology.

MOST 109-2327-B-182 -003 - Horng (co-PI) 2022/03/01 ~ 2026/02/28

The Research Center for Epidemic Prevention