A new verrucosane diterpenoid from the Vietnamese liverwort Plagiochila bantamensis

Chúng tôi vui mừng thông báo rằng TS. Lê Thị Kim Dung và các đồng nghiệp đã xuất bản công trình có tựa đề “A new verrucosane diterpenoid from the Vietnamese liverwort Plagiochila bantamensis” trên tạp chí Journal of Asian Natural Products Research.

Tóm tắt:

A new verrucosane-type diterpenoid, bantamenside (1), along with six known compounds (2–7), was isolated from the Vietnamese liverwort Plagiochila bantamensis. The structure of the new compound was determined using comprehensive spectroscopic methods, including 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Furthermore, all isolated compounds were evaluated for their ability to inhibit nitric oxide (NO) production. Compounds 1–3 and 6–7 demonstrated notable NO inhibitory activity, with IC₅₀ values ranging from 12.85 to 51.37 µM, outperforming or comparable to that of the positive control L-NMMA (IC₅₀ 41.30 ± 6.60 µM).