Three new constituents from the stems of Knema globularia and their α-glucosidase inhibitory activity

Chúng tôi vui mừng thông báo rằng TS. Lê Thị Kim Dung và các đồng nghiệp gần đây đã xuất bản công trình của họ có tựa đề "Three new constituents from the stems of Knema globularia and their α-glucosidase inhibitory activity" trên tạp chí Natural Product Research

Tóm tắt:

Three new metabolites (1−3) were isolated from the stems of Knema globularia, along with five known compounds, including kaempferol (4), quercetin (5), isovanillic acid (6), protocatechuic acid (7), and gallic acid (8). Their structures were deduced using NMR spectroscopic, mass spectrometric analyses, and literature data. The absolute configurations of 1−3 were established by electronic circular dichroism (ECD) spectroscopy. α-Glucosidase inhibitory activities of those compounds were evaluated using a spectrophotometric method, compounds 1−3 showed very strong effects towards α-glucosidase with IC50 values 1.59, 0.58 and 1.37 µM, respectively (the positive control, acarbose, IC50 93.63 µM). Simultaneously, enzyme kinetics study indicated that 2 was a mix-type inhibitor. 2 interacted well in the active site of α-glucosidase enzyme, primarily through hydrogen bonds and hydrophobic interactions.