A new diphenyl ether from the cultured lichen mycobiont of Graphishandelii

Chúng tôi vui mừng thông báo rằng ThS. Đỗ Thanh Hùng và các đồng nghiệp gần đây đã xuất bản công trình của họ có tựa đề "A new diphenyl ether from the cultured lichen mycobiont of Graphis cf. handelii" trên tạp chí Natural Product Research.

Tóm tắt:

Lichen is well-known for its various purposes. However, understanding the chemical composition and antimicrobial characteristics of Graphis cf. handelii remains insufficient. In this study, a new compound, graphinone A (1), together with three known compounds, handelone (2), 4-O-methylhiascic acid (3), and ethyl orsellinate (4) were isolated and structurally elucidated. Their chemical structures were established using comprehensive spectroscopic data (1D- and 2D-NMR and HRESIMS). Compounds 1–4 were tested for antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and evaluated for the alpha-glucosidase inhibition.