I earned my bachelor’s and master’s degrees from Hanoi University of Science and Technology and my PhD from the Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST). I currently work in the Department of Heterocyclic Chemistry, Institute of Chemistry, VAST, and also serve as a full-time lecturer at Ton Duc Thang University.

My research focuses on organic chemistry, particularly the design, synthesis, and optimization of biologically active compounds for pharmaceutical and related technological applications. I have hands-on experience operating advanced research equipment, including continuous-flow chemistry systems such as the Vapourtec E-Series and Chemtrix KiloFlow, as well as analytical and structural characterization instruments such as HPLC and high-resolution liquid chromatography–mass spectrometry (LC-HRMS/QTOF, SCIEX X500R).

My principal research interests include the development of efficient organic synthetic methods; the design and synthesis of bioactive compounds; investigation of the chemical constituents and biological activities of natural products; and the application of continuous-flow technology to optimize reaction conditions, improve yields, and enhance process control.

In recent years, I have increasingly integrated experimental research with computational chemistry, particularly density functional theory (DFT) for investigating and elucidating reaction mechanisms, and molecular docking for the design, screening, and synthesis-oriented prioritization of potentially bioactive compounds.

ONGOING PROJECTS

1. Role: Principal Investigator

• Project title: Development of a continuous-flow process for synthesizing clozapine as an active pharmaceutical ingredient for the treatment of schizophrenia and psychotic disorders
• Funding: Ministry of Science and Technology
• Budget: VND 6,470,000,000
• Duration: 2025–2027

2. Role: Principal Investigator

• Project title: Investigation of the chemical constituents of Scutellaria baicalensis Georgi processed using traditional medicine methods, employing high-resolution LC-MS/QTOF analysis
• Funding: Vietnam Academy of Science and Technology
• Budget: VND 600,000,000
• Duration: 2025–2027

3. Role: Key Member

• Project title: Development of a Category I excellent research group for the discovery, development, and prospective applications of novel sulfur- and nitrogen-containing heterocyclic structures with interesting properties
• Funding: Vietnam Academy of Science and Technology
• Budget: VND 5,900,000,000
• Duration: 2025–2027

4. Role: Key Member

• Project title: Project: Development of technology for synthesizing C8–C16 hydrocarbons from microalgal lipids using nanocatalysts for potential aviation fuel applications
• Funding: Vietnam Academy of Science and Technology
• Budget: VND 5,850,000,000
• Duration: 2025–2028

COMPLETED PROJECTS

a) National level / NAFOSTED

1. Project title: Research on the Continuous-Flow Synthesis of Celecoxib as an Active Pharmaceutical Ingredient for Anti-inflammatory and Analgesic Drugs.

• Project code: CNHD.DT.044/13-14
• Role: Key Member
• Date of acceptance: 2015

2. Project title: Synthesis and Screening of Anti-inflammatory and Anticancer Activities of Novel Compounds Based on Podophyllotoxin and Diaryl Stilbene Structures.

• Project code: 104.01-2015.90
• Role: Key Member
• Date of acceptance: 2019

3. Project title: Development and Optimization of Pilot-Scale Celecoxib Synthesis Technology Meeting USP Standards and Production of Celecoxib Capsules on a WHO-GMP-Compliant Manufacturing Line.

• Project code: CNHD.DASXTN.022
• Role: Key Member
• Date of acceptance: 2019

b) Ministerial, Provincial / Municipal level

1. Project title: Synthesis and Biological Evaluation of Novel Quinoline Derivatives of Podophyllotoxin.

• Project code: VAST 04.07/20-21
• Role: Principal Investigator
• Date of acceptance: 2023

2. Project title: Identification of Toxic Compounds Formed During Traditional Food Processing in Vietnam.

• Project code: VAST.TĐ.TP.03/16-18
• Role: Key Member
• Date of acceptance: 2018

3. Project title: Synthesis and Biological Evaluation of Novel Indole Alkaloid Derivatives.

• Project code: VAST 04.04/15-16
• Role: Key Member
• Date of acceptance: 2016

4. Project title: Investigation of Sulfur-Mediated Oxidation–Reduction Reactions for the Synthesis of Heterocyclic Compounds.

• Project code: KHCBHH.01/18-20
• Role: Key Member
• Date of acceptance: 2020

5. Project title: Research and Development of Fire-Extinguishing Powder Materials and Products.

• Project code: TĐPCCC.01/18-20
• Role: Key Member
• Date of acceptance: 2020

6. Project title: Investigation and Development of Traditional Herbal Remedies for Liver and Biliary Disorders Used by Ethnic Communities in Northwestern Vietnam.

• Project code: KHCN-TB.11C/13-18
• Role: Key Member
• Date of acceptance: 2019

7. Project title: Investigation of Antiviral Activities Against Swine Pathogens of Bioactive Compounds Isolated from Stixis scandens Lour. in Vietnam.

• Project code: ĐLTE00.07/21-22
• Role: Key Member
• Date of acceptance: 2023

8. Project title: Identification of Toxic Compounds and Quality Assessment in the Preservation and Processing of Plant-Derived Foods.

• Project code: TĐNDTP.00/19-21
• Role: Key Member
• Date of acceptance: 2021

c) Institutional / Enterprise level

1. Project title: Synthesis of Furan–Quinoline Compounds.

• Project code: VHH2020.2.05
• Role: Principal Investigator
• Date of acceptance: 2020

2. Project title: Isolation of Bioactive Compounds from Stixis suaveolens (Roxb.) Pierre (Capparaceae).

• Project code: VHH2019.2.02
• Role: Principal Investigator
• Date of acceptance: 2019

3. Project title: Stereoselective Synthesis of Dihydrocyanoanhydrovinblastine Derivatives.

• Project code: VHH2016.2.04
• Role: Principal Investigator
• Date of acceptance: 2016

Undergraduate

Outstanding publications

1. Nguyen Thi Kim Anh, Tran Thi Yen, Nguyen Ngoc Chien, Ngo Quoc Anh, and Nguyen Thi Thuy Hang*, “Optimization of the intramolecular cyclization to form the clozapine lactam intermediate under continuous-flow conditions and elucidation of the H2SO4-catalyzed mechanism by DFT”, RSC advances (2026), DOI: 10.1039/d6ra09280b

2. Thuy Hang Nguyen Thi, Yen Tran Thi, Le Anh Nguyen, Ngoc Binh Vo, Quoc Anh Ngo*, “ Design, Synthesis and Biological Activities of New Pyrazole Derivatives Possessing Both Coxib and Combretastatins Pharmacophores”, Chemistry & Biodiversity (2019), DOI: 10.1002/cbdv.201900108

3. Thi Thuy Hang Nguyen, Le Anh Nguyen, Minh Quan Pham, Ngoc Binh Vo, Quoc Anh Ngo. “Multicomponent synthesis of new 5-thiourea-4-aza-2,3 didehydropodophyllotoxins as potent cytotoxic agents”, J Heterocyclic Chem (2023), DOI: 10.1002/jhet.4633

4. Quoc Anh Ngo, Thuy Hang Nguyen Thi, Minh Quan Pham, Domenico Delfino & Thi Thao Do. “Antiproliferative and antiinflammatory coxib–combretastatin hybrids suppress cell cycle progression and induce apoptosis of MCF7 breast cancer cells”, Molecular Diversity (2020), DOI :10.1007/s11030-020-10121-2

5. Nguуen Thi Thuy Linh , Duc Long Le , Nguyen Thi Thuy Hang , Do Van Truong , Nguyen Thi Le Huyen , Dao Thi Van , Tran Khac Vu & Quoc Anh Ngo. “Phуtoсhemiсаl соnstituents оf Impаtiens siсulifera with nitriс оxide prоduсtiоn аnd alphaglucosidase inhibitоrу асtivities”, Natural Product Research (2025), DOI: 10.1080/14786419.2025.2597511