Natural Inhibitors Against Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease From Three Vietnamese Bryophytes

Chúng tôi vui mừng thông báo rằng TS. Lê Thị Kim Dung và các đồng nghiệp  đã xuất bản công trình có tựa đề “Natural Inhibitors Against Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease From Three Vietnamese Bryophytes” trên tạp chí Chemistry & Biodiversity.

Tóm tắt:

Erythrodontium julaceum, Marchantia polymorpha, and Plagiochila bantamensis are widely distributed bryophytes in Vietnam. However, comprehensive chemical and biological data on their composition remain limited. Bio-guided isolation based on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mpro inhibition was applied to these species, resulting in the identification of 23 metabolites. Compound P8 is a new natural compound. Subsequently, the SARS-CoV-2 Mpro inhibition of the isolated compounds revealed that bisbibenzyl- and 3-benzylphthalide-type compounds exhibit bioactivity. Among the tested compounds, isoriccardin C (M2) and julacelide (E1) exhibited significant activity, with IC50 values of 15.7 and 2.84 µg/mL, respectively. Molecular docking results further supported their strong activity.