Varoglutamstat Inhibits the Dimerization of the Aβ25–35 Fragment in Aqueous Solution

We are pleased to announce that Dr. Ngo Son Tung and colleagues recently published their work titled Varoglutamstat Inhibits the Dimerization of the Aβ25–35 Fragment in Aqueous Solution" in The Journal of Physical Chemistry B
Abstract:

The self-aggregation of amyloid-beta (Aβ) peptides is strongly associated with Alzheimer's disease. In this study, the influence of the small varoglutamstat compound on the conformations of the FAβ25–35 dimer was extensively characterized by using MD simulations. The influence of the ligand on the conformation of the FAβ25–35 dimer was studied during the first 10.0 μs. However, its real influence was clarified when the trajectory was extended to 20.0 μs. This indicates that the investigation of a ligand inhibiting Aβ requires a longer MD simulation than previously thought. The ligand changes ensemble properties by reducing the formation of nonbonded intermolecular contacts and β-content. Although varoglutamstat has weak binding to the FAβ25–35 dimer, the free energy landscape is impacted in shape, free energy barrier, and number of minima. Notably, it is found that the population of the amyloid-competent dimer structure is significantly reduced upon ligand addition. Furthermore, the change from β-hairpin conformation to antiparallel structure may occur through a transition state forming a random coil conformation.