Seminar on the topic: Frontiers in Bioactive Compounds: Discovery, Authentication, and Therapeutic Modulation

At 2:00 p.m. on September 5, 2025, IAST organized an academic exchange session at the Meeting Room on the 5th Floor of the Library - Ton Duc Thang University with the following detailed content:

1/ Dr. Tran Huynh Nguyen Khanh reported on the topic "Discovery of Bioactive Natural Products from Marine Sponge"
Abstract:

Twenty new terpenoids, coscinoderines A−J (1−10) and coscinins A−J (11−20), together with four known compounds (21–24), were isolated from the marine sponge Coscinoderma bakusi. Each coscinoderine contains a 1,2,5-trisubstituted pyridinium moiety bearing a terpene unit at the C-2 position whereas coscinin presents neomanoalide derivatives with 6,7-double bond geometry linking terpenoid moieties. Coscinin J is independently duplicated to halisulfate but contains an N-methylated α, β-unsaturated γ-lactam instead of a furan. Their structures were elucidated by analysis of NMR, HRMS data, calculated and measured ECD spectra. Most of the compounds showed little activities in assays targeting hTRPA1, 6 pathogenic bacterial strains, 10 cancer cell lines, and NO production in LPS-activated RAW 246.7 macrophage..

2/ Associate Professor, Dr. Nguyen Truong Huy reported on the topic "Metabolomics approach for the authentication of Panax vietnamensis varieties."
Abstract:

Panax vietnamensis var fuscidiscus (PVF) and Panax vietnamensis var vietnamensis (PVV) are two varieties of Panax vietnamensis that exhibit similarities in chemical composition and morphology, making them challenging for consumers to differentiate, despite different economic values. This study establishes a metabolomics approach for the authentication of these two varieties. Samples were first collected and then verified by ITSr-DNA sequencing data. Then PVF and PVV samples were set as the training set and utilized to explore discriminant markers by PLS-DA model. Consequently, thirteen ginsenosides were found as candidate markers. Seven are found in PVV including majonoside R2, vina-ginsenoside R13, ginsenoside Rd, ginsenoside Rb1, notoginsenoside Fa, pseudoginsenoside Rs1, and quinquenoside R1; Whereas, the other six markers were prevalent in PVF, including majonoside R1, vina-ginsenoside R2, ginsenoside Rb2, notoginsenoside Fc, notoginsenoside R2, and notoginsenoside R4. These markers were confirmed utilized a subsequent test set, confirming this as a highly efficient method for the quality control of Panax vietnamensis varieties.

3/ PhD. Nguyen Ngoc Tuan reported on the topic "Gut mucosal microbiome is perturbed in rheumatoid arthritis mice and partly restored after TDAG8 deficiency or suppression by salicylanilide derivative"
Abstract:

Rheumatoid arthritis (RA), an autoimmune disease, is characterized by chronic joint inflammation and pain. We previously found that the deletion of T-cell death-associated gene 8 (TDAG8) significantly reduces disease severity and pain in RA mice. Whether it is by modulating gut microbiota remains unclear. In this study, 64 intestinal samples of feces, cecal content, and cecal mucus from the complete Freund’s adjuvant-induced arthritis mouse models were compared. The α- and β-diversity indices of the microbiome were significantly lower in RA mice. Cecal mucus showed a higher ratio of Firmicutes to Bacteroidetes in RA than healthy mice, suggesting the ratio could serve as an RA indicator. Four core genera, Eubacterium_Ventriosum, Alloprevotella, Rikenella, and Treponema, were reduced in content in both feces and mucus RA samples, and could serve microbial markers representing RA progression. TDAG8 deficiency decreased the abundance of proinflammation-related Eubacterium_Xylanophilum, Clostridia, Ruminococcus, Paraprevotella, and Rikenellaceae, which reduced local mucosal inflammation to relieve RA disease severity and pain. The pharmacological block of the TDAG8 function by a salicylanilide derivative partly restores the RA microbiome to a healthy composition. These findings provide a further understanding of specific bacteria interactions with host gut mucus in the RA model. The modulation by TDAG8 on particular bacteria can facilitate microbiota-based therapy.

4/ PhD. Le Thi Kim Dung reported on the topic "Isolation and Characterization of Bioactive Compounds from Knema globularia Stems"
Abstract:

Twelve new compounds (1−12), along with fourteen known analogues 13−26 were isolated from the stems of Knema globularia. The structures of new compounds were elucidated by the comprehensive spectroscopic analysis, including UV, IR, HRESIMS, and NMR; the absolute configurations were determined based on their NOESY data, DP4+ statistical analysis, and ECD calculation. Globunones A−E (1−5) represent the initial combined structures of a flavan-3-ol core and a 1,4-benzoquinone core. Up to now, compounds 10 and 11 represent the first 3,3″-linked biflavanone structures. Most compounds tested potently inhibited a-glucosidase and a-amylase activities.

Dr. Tran Huynh Nguyen Khanh presented the report

Assoc. Prof., Dr. Nguyen Truong Huy presented the report

Dr. Nguyen Ngoc Tuan presented the report.

Dr. Le Thi Kim Dung presented the report.

Director of Advanced Technology Institute presents gifts to guests