Chemical constituents with their alpha-glucosidase inhibitory activity from the whole plant of Ceratophyllum demersum

We are happy to announce that Dr. Le Thi Kim Dung and colleagues recently published their work entitled "Chemical constituents with their alpha-glucosidase inhibitory activity from the whole plant of Ceratophyllum demersum" in the Phytochemistry

 Abstract:

From Ceratophyllum demersum growing in Vietnam, twelve compounds were isolated and structurally elucidated, including six previously undescribed compounds, demersones A-D (1–4), acetylvelutins A and B (8 and 9), together with six known compounds, (+)-cyclocolorenone (5), 1-hydroxycyclocolorenone (6), 10-hydroxycyclocolorenone (7), retusin (10), betulinic acid (11), and lupeol (12). The chemical structures and stereochemistry of 1–12 were identified through analysis of spectroscopic data (1D and 2D NMR and HRESIMS), ECD data, and DFT calculation. Notably, this is the first time that humulene-type (1 and 2), guaiane-type (3), and aromadendrane-type (4–7) sesquiterpenoids have been reported in this genus. Compounds 8 and 9 are the first examples of 8-acetoxyflavones found in nature. Upon evaluation of the alpha-glucosidase of 1–3 and 5–12, it was found that 12 exhibited the highest potential with an IC₅₀ value of 15.4 ± 1.1 μM. The molecular docking of 3 and 8 was further studied.