A new diphenyl ether from the cultured lichen mycobiont of Graphishandelii

We are happy to announce that MSc. Do Thanh Hung and colleagues recently published their work entitled "A new diphenyl ether from the cultured lichen mycobiont of Graphis cf. handelii" in the Natural Product Research.

Abstract:

Lichen is well-known for its various purposes. However, understanding the chemical composition and antimicrobial characteristics of Graphis cf. handelii remains insufficient. In this study, a new compound, graphinone A (1), together with three known compounds, handelone (2), 4-O-methylhiascic acid (3), and ethyl orsellinate (4) were isolated and structurally elucidated. Their chemical structures were established using comprehensive spectroscopic data (1D- and 2D-NMR and HRESIMS). Compounds 1–4 were tested for antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and evaluated for the alpha-glucosidase inhibition.